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This suggests that NP4 could effectively promote the polarization of M2-type macrophages towards M1-type macrophages, thereby alleviating immune suppression

For example, studies have found that triple-negative breast cancer (TNBC) competes for Gln uptake in the environment, limiting Gln metabolism in tumor-infiltrating T cells and inhibiting anti-tumor responses

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McEwen has defined allostatic load as the cost of chronic exposure to fluctuating or heightened neural or neuroendocrine response resulting from repeated or chronic environmental challenge that an individual reacts to as being particularly stressful (287)